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Take into account alternant therapies that aren't reasonable CYP3A inducers during treatment method with mitapivat. If not able to prevent coadministration, check Hb and titrate over and above 50 mg BID, if required, but don't exceed mitapivat dose of 100 mg BID. .pentobarbital will decrease the level or impact of bortezomib by affecting hepatic/in